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KMID : 0614720130560110972
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Journal of Korean Medical Association
2013 Volume.56 No. 11 p.972 ~ p.982
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Recent advance in international management of hepatocellular carcinoma
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Chung Jin-Wook
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Abstract
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During the most recent decade, remarkable progress has taken place in intra-arterial therapy for hepatocellular carcinoma. Advances in knowledge of hepatic vascular anatomy and tumor blood supply have contributed to the safety and efficacy of intra-arterial therapies. Technological advances in C-arm computed tomography and microcatheter systems have improved the technical success rates for superselective or ultraselective catheterization of tumor-feeding arteries. Drug-eluting bead technology has provided the option of performing chemoembolization with less systemic exposure to anticancer drugs and a more standardized delivery. Radio-embolization with yttrium-90 microspheres has emerged as a promising option offering increased quality of life. In addition, chemoembolization plays a central role in recently developed combination therapy strategies. In this era of advanced technologies and new treatment options, efforts should be made to understand the advantages and disadvantages of new technologies and treatment strategies and to apply them properly, which may lead to better local control of tumors, better quality of life, and longer patient survival.
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KEYWORD
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Hepatocellular carcinoma, Chemoembolization, Drug-eluting bead, Radioembolization
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